английский => русский Медицина Медицина: Кардиология Heart failure

Natriuretic peptides, which promote sodium excretion and diuresis, are secreted from the atria and ventricles in response to volume overload and increasing intramyocardial pressure. Initially, these compensatory mechanisms maintain cardiac output and blood pressure. Ultimately, however, these mechanisms increase preload, afterload, and myocardial work. Increases in left ventricular end-diastolic pressure and left ventricular wall stress lead to further reduction in cardiac output, further volume retention and, eventually, pulmonary congestion.