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breakthrough GvHD occurs

Russian translation: происходит обострение БТПХ

23:24 May 22, 2017
English to Russian translations [PRO]
Science - Biology (-tech,-chem,micro-)
English term or phrase: breakthrough GvHD occurs
In cases where breakthrough GvHD occurs (for example, even despite prophylaxis), treatment may be initiated immediately upon confirmation of Grade II or higher GvHD disease. Systemic corticosteroids such as methylprednisolone are the first-line treatment of choice, administered concurrently with ongoing prophylaxis with, for example, a calcineurin inhibitor such as ciclosporin or tacrolimus.
Where first-line treatment or prophylaxis fails to control GvHD, “salvage therapy” may be attempted in which case additional previously unused immunosuppressants such as rapamycin or mycophenolate mofetil may be administered.


В случаях, когда возникает БТПХ (например, даже несмотря на профилактику), лечение можно начать сразу же после подтверждения БТПХ II-й степени или выше. Кортикостероиды для системного применения, как, например, метилпреднизолон, относятся к лечению первой линии, которое можно осуществлять параллельно с профилактикой, например, ингибиторами кальциневрина, как, например, циклоспорином или такролимусом.

Если лечение или профилактика первой линии не обеспечивает подавление БТПХ, можно прибегнуть к «терапии спасения», в случае чего можно применять дополнительные ранее неиспользованные иммуносупрессоры, такие как рапамицин или мофетил микофенолата.

не совсем понятно, как перевести "the first-line treatment of choice, administered concurrently with ongoing prophylaxis"

Спасибо!
dao2812
Russian translation:происходит обострение БТПХ
Explanation:
или "обострение реакции отторжения".
Selected response from:

cherepanov
Ukraine
Local time: 04:24
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Summary of answers provided
3происходит обострение БТПХ
cherepanov


  

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6 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
breakthrough gvhd occurs
происходит обострение БТПХ


Explanation:
или "обострение реакции отторжения".

cherepanov
Ukraine
Local time: 04:24
Specializes in field
Native speaker of: Native in RussianRussian
PRO pts in category: 320
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