الجرعة الأولية الثابتة من العلاج التوليفي القائم على مادة الأرتيميسينين لصغار الأطفال/الأطفال الرضع

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Note added at 2 hrs (2009-07-24 13:37:59 GMT)
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العلاج التوليفي القائم على مادة الأرتيميسينين

Artemisinin-based Combination Therapy (ACT)

Currently artemisinin-based combination therapy (ACT) is recommended for the treatment of P. falciparum malaria. Fast acting artemisinin-based compounds are combined with a drug from a different class. Companion drugs include lumefantrine, mefloquine, amodiaquine, sulfadoxine/pyrimethamine, piperaquine and chlorproguanil/dapsone. Artemisinin derivatives include dihydroartemisinin, artesunate and artemether. Implementation of the recommendation to use ACTs is limited by the small number of available and affordable co-formulated anti-malarial drugs, but most countries are now starting to implement this regimen. A co-formulated drug is one, in which two different drugs are combined in one tablet; this is important to ensure both drugs are used.

http://www.malariaconsortium.org/page.php?id=112

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Note added at 2 hrs (2009-07-24 13:44:38 GMT)
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Artemisinin (pronounced /ɑrtɨˈmɪsɨnɨn/) is a drug used to treat multi-drug resistant strains of falciparum malaria. The compound (a sesquiterpene lactone) is isolated from the plant Artemisia annua. Not all plants of this species contain artemisinin. Apparently it is only produced when the plant is subjected to certain conditions, most likely biotic or abiotic stress. It can be synthesized from artemisinic acid.[1] The drug is derived from a herb used in Chinese traditional medicine, though it is usually chemically modified and combined with other medications.

Use of the drug by itself as a monotherapy is explicitly discouraged by the World Health Organization as there have been signs that malarial parasites are developing resistance to the drug. Combination therapies that include artemisinin are the preferred treatment for malaria and are both effective and well tolerated in patients. The drug is also being studied as a treatment for cancer.