English to Russian Medical Medical: Health Care

TBX3 encodes a transcriptional repressor, mutations of which underlie the developmental disorder **ulnar-mammary syndrome** that is characterized by mammary gland hypoplasia, limb defects, and other congenital abnormalities. TBX3 is a negative regulator of apoptosis, at least in part by repressing p14ARF expression. The TBX3 C-terminus contains a repressor domain required for transcriptional repression and cell immortalization; however, somatic truncating mutations have recurrently been identified in breast cancer.