Glossary entry

English term or phrase:

conditioned fear stress-induced freezing behavior test

Russian translation:

тест на реакцию замирания, вызванную условно-рефлекторным страхом

Added to glossary by Igor_2006
Feb 27, 2020 10:47
4 yrs ago
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English term

conditioned fear stress-induced freezing behavior test

English to Russian Medical Medical: Pharmaceuticals Nonclinical Overview
Effects of Lurasidone in Animal Models of Mood Disorders
Lurasidone was evaluated for its antidepressant- and anxiolytic-like effects through a series of behavioral experiments including the conditioned fear stress-induced freezing behavior test, Vogel water lick conflict test, the conditioned defensive burying test, and the social interaction test.
In brief, lurasidone significantly modified these behaviors in a manner similar to that observed for other anxiolytic, atypical antipsychotic, or antidepressant drugs used as positive controls.
Change log

Mar 3, 2020 04:43: Igor_2006 Created KOG entry

Proposed translations

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Selected

тест на реакцию замирания, вызванную условно-рефлекторным страхом

Freezing behavior induced by footshock and conditioned fear stress in rodents are widely accepted as models for evaluating the level of anxiety. Rodents exhibit freezing behavior when aversive stimulation is given.
https://patents.google.com/patent/CA2694881C/en

Процедура №2 – это процедура условно-рефлекторного обучения, в ходе
которого выработку условного рефлекса контролировали по увеличению
относительного времени пребывания животного в состоянии замирания
(фризинг), возникающего на предъявление условного звукового сигнала. Под фризингом здесь и далее понимаем безусловную реакцию проявления страха, которая выражается в полном замирании животного в течение не менее 5 секунд.
https://disser.spbu.ru/files/phd_spsu/tsvetkov_disser.pdf
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