Oct 26, 2014 13:29
9 yrs ago
9 viewers *
English term
Native in: English 
mechanism of action and resistance biomarkers
English
Medical
Medical (general)
Hello!
This is from a clinical study, and I have trouble understanding parts of the sentence, might be a typo but client wouldn't respond...
Tumor biopsy will be performed at the time of the first restaging and/or at the time of progression in an optional first and/or second substudy to investigate pharmacodynamics, *mechanism of action and resistance biomarkers*.
Earlier it says:
Tumor biopsy will be performed at the time of the first restaging in an optional substudy to investigate *pharmacodynamic and mechanism of action biomarkers.*
Is here simply an "of" missing?
Thank you!
This is from a clinical study, and I have trouble understanding parts of the sentence, might be a typo but client wouldn't respond...
Tumor biopsy will be performed at the time of the first restaging and/or at the time of progression in an optional first and/or second substudy to investigate pharmacodynamics, *mechanism of action and resistance biomarkers*.
Earlier it says:
Tumor biopsy will be performed at the time of the first restaging in an optional substudy to investigate *pharmacodynamic and mechanism of action biomarkers.*
Is here simply an "of" missing?
Thank you!
Change log
Oct 26, 2014 13:35: writeaway changed "Language pair" from "German to English" to "English"
Responses
-1
4 hrs
mechanism of action and [mechanism of] resistance biomarkers
Biomarker a naturally occurring molecule, gene, or characteristic by which a particular pathological or physiological process, disease, etc. can be identified.
The statement should be read as: "mechanism of action and [mechanism of] resistance biomarkers." THis is similar to the earlier text, "mechanism of action biomarkers."
I do not think there is an "of" missing. Seems okay to me.
The statement should be read as: "mechanism of action and [mechanism of] resistance biomarkers." THis is similar to the earlier text, "mechanism of action biomarkers."
I do not think there is an "of" missing. Seems okay to me.
+1
10 hrs
mechanism of action and resistance biomarkers
The substudy will investigate three issues:
- pharmacodynamics (of the study drug in question) -
- mechanism of action (of the study drug in question)
- biomarkers of resistance (to the study drug in question)
- pharmacodynamics (of the study drug in question) -
- mechanism of action (of the study drug in question)
- biomarkers of resistance (to the study drug in question)
Reference comments
1 hr
Reference:
findings
"resistance biomarkers" and biomarkers of resistance" both seem to be used
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Note added at 1 hr (2014-10-26 14:42:15 GMT)
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mechanism of action
stands alone
as a phrase
not sure what your problem is here?
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Note added at 1 hr (2014-10-26 14:44:01 GMT)
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Novel biomarkers: neuroInflammation
www.neuroinflammation.eu/projects/novel-biomarkers.html
Stroke and MS are complex diseases with several mechanisms contributing ... biomarkers can provide insight into the mechanism of action of a drug and could ...
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Note added at 1 hr (2014-10-26 14:54:54 GMT)
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I am unable to find much with biomarkers mechanism of action/biomarker mechanism of action
The biomarkers are used to reflect the mechanism of action of the drug...
Biomarkers of Histone Deacetylase Inhibitor Activity in a ...
broker.edina.ac.uk/294189/1/PMC3934935.pdf
by AH Ree - 2014 - Related articles
25 Feb 2014 - ***An optimum biological dose may be the dose that is associated with pharmacodynamic biomarkers reflecting the mechanism of drug action***.
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Note added at 2 hrs (2014-10-26 16:09:38 GMT)
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personally, I think the text is poorly written
If I were you I would find a good bona fide English article on the subject and compare.
--------------------------------------------------
Note added at 1 hr (2014-10-26 14:42:15 GMT)
--------------------------------------------------
mechanism of action
stands alone
as a phrase
not sure what your problem is here?
--------------------------------------------------
Note added at 1 hr (2014-10-26 14:44:01 GMT)
--------------------------------------------------
Novel biomarkers: neuroInflammation
www.neuroinflammation.eu/projects/novel-biomarkers.html
Stroke and MS are complex diseases with several mechanisms contributing ... biomarkers can provide insight into the mechanism of action of a drug and could ...
--------------------------------------------------
Note added at 1 hr (2014-10-26 14:54:54 GMT)
--------------------------------------------------
I am unable to find much with biomarkers mechanism of action/biomarker mechanism of action
The biomarkers are used to reflect the mechanism of action of the drug...
Biomarkers of Histone Deacetylase Inhibitor Activity in a ...
broker.edina.ac.uk/294189/1/PMC3934935.pdf
by AH Ree - 2014 - Related articles
25 Feb 2014 - ***An optimum biological dose may be the dose that is associated with pharmacodynamic biomarkers reflecting the mechanism of drug action***.
--------------------------------------------------
Note added at 2 hrs (2014-10-26 16:09:38 GMT)
--------------------------------------------------
personally, I think the text is poorly written
If I were you I would find a good bona fide English article on the subject and compare.
Peer comments on this reference comment:
| agree |
Natalia Volkova
6 hrs
|
| agree |
uyuni
1 day 1 hr
|
| agree |
Phong Le
9 days
|
Discussion
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